Units on Thorp Arch trading estate will be demolished if a planning application is successful.
Rockspring Hanover Property Trust, which owns the site, have applied to demolish three industrial units in preparation for taking on new business.
The trading estate is also the subject of another planning application for up to 2,000 houses, also submitted by Rockspring, which has been pending consideration by Leeds City Council planners since July 2014.
The company, however, told the Wetherby News that the two were completely unrelated.
Tim Munns, from Rockspring agents Wharfedale Property Management, said: “This application is completely different to the residential proposal.
“We have a very significant application in for 2,000 houses, this application we have just submitted is a request for consent to demolish three buildings for commercial development at a further date.
“The residential proposal is pretty much the north half of the site and the intention is to retain the southern half for employment use.”
The applicant would demolish three buildings on the estate which accommodates 140 businesses and 2,000 employees.
International drinks wholesaler Matthew Clark have expressed an interest in relocating their business from York, and the demolition would make way for a new development expressly for this purpose.
Mr Munns reiterated: “There is no linkage between them. This is to clear a site prior to getting an occupier.”
Asked whether he had heard of any progress with the plans for 2,000 houses, Mr Munns said: “I am unable to give any information in relation to the residential proposal.
“It is a big application and it is taking a long period of time, and that is all I am able to say.”